Ọkwa ọgwụ dị ọcha dị elu 1421373-66-1 Mesylate-AZD9291 maka ọgwụgwọ ọrịa kansa.
| Ngwaahịaaha | AZD-9291 mesylate |
| Ụdị okwu | N-[2-[[2- (Dimethylamino) ethyl] methylamino] -4-methoxy-5-[[4- (1-methyl-1H-indol-3-yl) -2-pyrimidinyl] amino] phenyl] - 2-propenamide methanesulfonate (1: 1) |
| CAS Mba. | 1421373-66-1 |
| Ọdịdị | Ọcha na-acha odo odo siri ike ntụ ntụ |
| Usoro ihe omimi | C28H33N7O2.CH4O3S |
| Ibu molekụla | 595.71 |
| Ojiji | Ọkwa ọgwụ ma ọ bụ ebumnuche nyocha |
| Nkwakọ ngwaahịa | Dị ka arịrịọ gị si dị |
| Nchekwa | Chekwaa n'ime akpa siri ike, nke na-enweghị ọkụ n'ebe dị mma |
| AZD-9291 mesylateCAS: 1421373-66-1 | ||
| Item | Standards | Rpụta |
| Ọdịdị | Ọcha na-acha odo odo siri ike ntụ ntụ | Ìhè odo siri ike ntụ ntụ |
| Identification | Site na IR | Na-akwado |
| Nke HPLC | Na-akwado | |
| Solubility | Soluble na Dimethylsulfoxide, soluble ntakịrị na Ethanol na Acetonitrile, yana pH dabere na mmiri solubility. | Na-akwado |
| Ọdịnaya Mmiri (KF) | ≤ 1.00% | 0.42% |
| Ihe fọdụrụ na mgbanye | ≤0.10% | 0.05% |
| HmfeMetal | ≤20pm | Na-akwado |
| Mesylate | 15.20% ~ 18.20% | 15.90% |
| Ihe mgbaze fọdụrụnụ | Acetonitrile: ≤410ppm | ND |
| Acetone: ≤5000ppm | ND | |
| Tetrahydrofuran: ≤720ppm | ND | |
| Robi ụtọSihe | Otu adịghị ọcha kacha: ≤0.20% | 0.17% |
| Mkpokọta adịghị ọcha: ≤1.00% | 0.25% | |
| Oke urughuru | D90: ≤100μm | 57.97% |
| Akwuo (HPLC ndabere na ihicha) | 98.00% ~ 102.00% | 99.80% |
| Ụkpụrụ ntụaka | Standard n'ime ụlọ | |
Ozi ụlọ ọrụ
√ Ahụmahụ zuru oke nke oyi akwa na ụlọ ọrụ mmepụta ihe na ndị na-eso ụzọ teknụzụ nwere nkà; √ Quality bụ mgbe anyị n'elu echiche, siri ike QC usoro; √ 11 afọ nwere ahụmahụ mbupụ ahịa otu; √ ụlọ nyocha R&D nọọrọ onwe ya; √ Ụlọ ọrụ GMP abụọ bịanyere aka na ogologo oge; √ Akụ bara ụba nke ọtụtụ ụlọ ọrụ na-abaghị uru maka ọrụ ahaziri iche; √ Ndị otu na-arụ ọrụ nke ọma na ụzọ na-agbanwe agbanwe.
Dee ozi gị ebe a ziga anyị ya
